m-Chloroperbenzoic acid → Formic Acid 4-fluoro-3,5-dimethyl-phenyl ester

HRID 1361068ノート

反応式

HRID 1361068 の反応式
[F:1][C:2]1[C:9]([CH3:10])=[CH:8][C:5](C=O)=[CH:4][C:3]=1[CH3:11].C1C=C(Cl)C=C([C:19]([O:21]O)=[O:20])C=1>C(Cl)Cl>[F:1][C:2]1[C:3]([CH3:11])=[CH:4][C:5]([O:21][CH:19]=[O:20])=[CH:8][C:9]=1[CH3:10]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 120407104-Fluoro-3,5-dimethylbenzaldehyde

生成物 1

HCID 59775190Formic Acid 4-fluoro-3,5-dimethyl-phenyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
25 °C

実験手順

To a solution of 4-fluoro-3,5-dimethyl-benzaldehyde (1.0 g, 6.4 mmol) in 20 mL DCM was added mCPBA (1.2 g, 7.6 mmol) at 25° C. After being stirred for 20 h at 25° C., the reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate. The mixture was extracted DCM (3×30 mL) and the combined DCM layer was washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

後処理

  1. customthe reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate
  2. extractionThe mixture was extracted DCM (3×30 mL)
  3. washthe combined DCM layer was washed with brine (2×30 mL)
  4. dry with materialThe solution was dried over Na2SO4
  5. concentrationbefore being concentrated under reduced pressure
  6. customThe crude product was used directly in the next reaction without further purification

出典と根拠

ORDレコード
ord-e3a4f3bddc1644fea1604bc7bf43a7f1
出典データセット
uspto-grants-2011_02
特許番号
US07879911B2

反応ノート

読み込み中…