Diethylamine → (R)-methyl 2-amino-3-(tritylthio)propanoate

HRID 1361199

反応式

HRID 1361199 の反応式
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:24]([O:26][CH3:27])=[O:25])[CH2:3][S:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(NCC)C>C(#N)C>[NH2:1][C@H:2]([C:24]([O:26][CH3:27])=[O:25])[CH2:3][S:4][C:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

4

反応物 2

HCID 8021DiethylamineHCID 59278482Fmoc-Cys(Trt)-OMe

生成物 1

HCID 10429690(R)-methyl 2-amino-3-(tritylthio)propanoate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of Fmoc-L-Cys(Trt)-OMe (2.58 g, 4.30 mmol) in acetonitrile (20.0 mL) was added diethylamine (20.0 mL). After 30 minutes, the mixture was concentrated in vacuo. The residue was dissolved in acetonitrile (3×10 mL) and concentrated in vacuo to afford L-Cys(Trt)-OMe as crude product which was used without purification.

後処理

  1. concentrationthe mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved in acetonitrile (3×10 mL)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-a73bbe0d1984409fb42f1d02508a83d5
出典データセット
uspto-grants-2011_02
特許番号
US07879873B2

関連ノート

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