2-Thiazolamine, 5-bromo- → 3-isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)benzamide

反応式

[Br:1][C:2]1[S:6][C:5]([NH2:7])=[N:4][CH:3]=1.[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=1)[C:15](O)=[O:16])([CH3:10])[CH3:9]>>[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=1)[C:15]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:16])([CH3:10])[CH3:9]

参加物

反応物 2

HCID 436002-Thiazolamine, 5-bromo-

HCID 669698623-Isopropyloxy-5-phenoxybenzoic acid

生成物 1

HCID 866323843-isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)benzamide収率 82%

実験手順

3-Isopropyloxy-5-phenoxy-N-(5-bromothiazol-2-yl)-benzamide (1.1 g, 82%) was prepared from 5-bromo-2-aminothiazole (830 mg, 4.6 mmol) and 3-isopropyloxy-5-phenoxybenzoic acid (835 mg, 3.1 mmol) following the general procedure A.

出典と根拠

ORDレコード: ord-d1ab13ecd0a642caa0b17ac2d0d89c69
出典データセット: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07880012B2

反応ノート

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