1-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine → 2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

HRID 1361588ノート

反応式

HRID 1361588 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=2[N+:18]([O-])=O)[CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][C:9]=2[NH2:18])[CH2:6][CH2:7]1

参加物

4

反応物 1

HCID 28607241-Methyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine

生成物 1

HCID 6932882-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To 1-Methyl-4-(2-nitro-4-trifluoromethyl-phenyl)-piperazine (1.46 g, 5.05 mmol) in dry MeOH (50 mL) was added Pd/C (10%, 535 mg). H2 gas was bubbled through the solution at room temperature overnight with vigorous stirring. The reaction mixture was filtered through celite to provide, after concentration, the desired product as a white solid. MS (M+H)+=260; Calc'd 259.28 for C12H16F3N3.

後処理

  1. customH2 gas was bubbled through the solution at room temperature overnight with vigorous stirring
  2. filtrationThe reaction mixture was filtered through celite
  3. customto provide
  4. concentrationafter concentration

出典と根拠

ORDレコード
ord-964508dd143b4f2792d6daa4671bb2dc
出典データセット
uspto-grants-2011_02
特許番号
US07880000B2

反応ノート

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