Hydrochloric Acid → 1-Benzyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 1361897ノート

反応式

HRID 1361897 の反応式
[CH2:1]([N:8]1[CH:13]=[CH:12][C:11]([C:14]([O:16]CC2C=CC=CC=2)=[O:15])=[CH:10][C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO.O>[CH2:1]([N:8]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]1=[O:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23144210Benzyl 1-benzyl-2-oxo-1,2-dihydropyridine-4-carboxylate

生成物 1

HCID 181796161-Benzyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid収率 20%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

Benzyl 1-benzyl-2-oxo-1,2-dihydropyridine-4-carboxylate (1.08 g, 3.38 mmol) obtained in Step 2 was dissolved in a mixed solvent of methanol (7 mL) and water (7 mL), and sodium hydroxide (0.680 g, 16.9 mmol) was added thereto, followed by stirring under heating and reflux for 30 minutes. The reaction mixture was poured into water (50 mL), and 10% hydrochloric acid was added thereto to adjust the pH to 4.5, followed by stirring at room temperature for 1 hour. The precipitated solid was collected by filtration to afford the entitled Compound w (151 mg, 20%) as a white solid.

後処理

  1. additionwas added
  2. temperatureunder heating
  3. temperaturereflux for 30 minutes
  4. additionwas added
  5. stirringby stirring at room temperature for 1 hour
  6. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-52851ecc56bb4142b0d4b1e132cd0d16
出典データセット
uspto-grants-2011_02
特許番号
US07880013B2

反応ノート

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