HCID 7269394、化合物 → Ethyl 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate

HRID 1361912ノート

反応式

HRID 1361912 の反応式
[CH3:1][C:2]1([CH3:14])[O:6][C@H:5](/[CH:7]=[CH:8]/[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:4][O:3]1>[Pd].CO>[CH3:1][C:2]1([CH3:14])[O:6][C@H:5]([CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:4][O:3]1

参加物

4

反応物 1

HCID 7269394HCID 7269394、化合物

生成物 1

HCID 22831642Ethyl 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a methanol (200 mL) solution of ethyl (2E)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate (15.3 g, 76.7 mmol) was added 10% palladium on carbon (1.5 g). The reaction mixture was stirred under an atmosphere of hydrogen overnight. The catalyst was removed by filtration, and the solvent was removed in vacuo. Chromatography over silica afforded the title compound. 1H NMR (400 MHz, CDCl3): δ 4.05-4.15 (m, 2H), 4.02-4.04 (m, 2H), 3.52-3.55 (m, 1H), 2.30-2.47 (m, 2H), 1.83-1.90 (m, 2H), 1.33 (s, 3H), 1.26 (s, 3H), 1.21 (t, J=6.8 Hz, 3H).

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-abb701668b8f438ea180783a7c4649c6
出典データセット
uspto-grants-2011_02
特許番号
US07880014B2

反応ノート

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