Piperidine → 5-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamine

HRID 1362097

反応式

HRID 1362097 の反応式
Br.[Br:2][C:3]1[CH:4]=[C:5]([CH2:10]Br)[C:6]([NH2:9])=[N:7][CH:8]=1.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CC#N.CCOCC>[Br:2][C:3]1[CH:4]=[C:5]([CH2:10][N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[C:6]([NH2:9])=[N:7][CH:8]=1

参加物

5

反応物 2

HCID 8082PiperidineHCID 534200525-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

生成物 1

HCID 594569835-Bromo-3-piperidin-1-ylmethyl-pyridin-2-ylamine収率 53.5%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6342Acetonitrile溶媒

実験手順

An ice-cold suspension of 5-bromo-3-bromomethyl-pyridin-2-ylamine hydrobromide (10.0 g, 28.8 mmol) in MeCN (100 mL) was treated with piperidine (6.4 mL, 64.8 mmol). After stirring at room temperature for 3.5 h, the mixture was diluted with Et2O (500 mL). The solution was filtered and then concentrated to give the title compound (4.16 g, 53%) as a pale, yellow solid: MS (ESI) m/e 270 (M+H)+.

後処理

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-7b1adbb30ca24a069da8dc51c1197c74
出典データセット
uspto-grants-2011_02
特許番号
US07879872B2

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