Tri-o-tolylphosphine → (E)-3-(2-aminopyrimidin-5-yl)-N-(2-methyl-1H-indol-3-ylmethyl)-N-methylacrylamide

反応式

[CH3:1][N:2]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][C:9]=1[CH3:17])[C:3](=[O:6])[CH:4]=[CH2:5].[NH2:18][C:19]1[N:24]=[CH:23][C:22](Br)=[CH:21][N:20]=1.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(C(C)C)CC)(C)C>C(#N)CC.CN(C=O)C.CC([O-])=O.CC([O-])=O.[Pd+2]>[NH2:18][C:19]1[N:24]=[CH:23][C:22](/[CH:5]=[CH:4]/[C:3]([N:2]([CH2:7][C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[CH3:17])[CH3:1])=[O:6])=[CH:21][N:20]=1