Dimethylformamide → 3-Isopropylbenzofuran-2-carbaldehyde

HRID 1362399ノート

反応式

HRID 1362399 の反応式
[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH:5]=1)([CH3:3])[CH3:2].[Li]CCCC.CN([CH:21]=[O:22])C>C1COCC1>[CH:1]([C:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][C:5]=1[CH:21]=[O:22])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 112174123-IsopropylbenzofuranHCID 178418339Butyllithium

生成物 1

HCID 577420813-Isopropylbenzofuran-2-carbaldehyde

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a cooled (0° C.) solution of 3-isopropylbenzofuran (250 mg, 1.56 mmol) in THF (1 mL) is added nBuLi (2 mL, 2 mmol) drop wise and the reaction is stirred for 30 minutes. DMF (1 mL) was added to the reaction and stirred at room temperature overnight. The solution is placed in an ice bath and carefully quenched with 5% aqueous HCl solution (2 mL), and extracted with ethyl acetate (3×5 mL), dried over sodium sulfate and concentrated. The product was purified on silica with 100% hexanes to yield title compound in as a colorless oil (250 mg, 85%): 1H NMR (400 MHz, CDCl3) δ 10.10 (s, 1H), 7.78 (d, 1H, J=9.0 Hz), 7.55 (d, 1H, J=9.0 Hz), 7.32-7.24 (m, 2H), 3.11-3.07 (m, 1H), 1.33-1.31 (2s, 6H).

後処理

  1. stirringstirred at room temperature overnight
  2. customThe solution is placed in an ice bath
  3. customcarefully quenched with 5% aqueous HCl solution (2 mL)
  4. extractionextracted with ethyl acetate (3×5 mL)
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated
  7. customThe product was purified on silica with 100% hexanes

出典と根拠

ORDレコード
ord-6fc955e1185a4719ae21bbc3218b853c
出典データセット
uspto-grants-2011_02
特許番号
US07879872B2

反応ノート

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