Hydrochloric Acid → 2,3-Difluorophenyl propionate

HRID 1362498ノート

反応式

HRID 1362498 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[C:10](Cl)(=[O:13])[CH2:11][CH3:12].Cl>ClCCl.N1C=CC=CC=1>[C:10]([O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[F:1])(=[O:13])[CH2:11][CH3:12]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 808792,3-Difluorophenol

生成物 1

HCID 669694902,3-Difluorophenyl propionate収率 105.2%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

20 g (153.7 mmol) of 2,3-difluorophenol in 150 ml of dichloromethane and 17.5 ml of pyridine are admixed dropwise at 0° C. with 14 ml (161 mmol) of propionyl chloride. The mixture is stirred for two hours and 100 ml of 2 M hydrochloric acid are added. The mixture is extracted with dichloromethane and the extracts are washed with water. Drying over sodium sulphate and the removal of the solvent in vacuo give 30.1 g of 2,3-difluorophenyl propionate.

後処理

  1. extractionThe mixture is extracted with dichloromethane
  2. washthe extracts are washed with water
  3. dry with materialDrying over sodium sulphate
  4. customthe removal of the solvent in vacuo

出典と根拠

ORDレコード
ord-f81e89d20163424890f98d077e8c1f16
出典データセット
uspto-grants-2011_02
特許番号
US07880042B2

反応ノート

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