1,3-Cyclohexanedione → 2-Bromocyclohexane-1,3-dione

HRID 1364080ノート

反応式

HRID 1364080 の反応式
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[Br:9]Br>CC(O)=O>[Br:9][CH:2]1[C:3](=[O:7])[CH2:4][CH2:5][CH2:6][C:1]1=[O:8]

参加物

4

反応物 2

HCID 104341,3-CyclohexanedioneHCID 24408Bromine

生成物 1

HCID 27704762-Bromocyclohexane-1,3-dione

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a stirred solution of cyclohexane-1,3-dione (1.12 g, 10 mmol) in AcOH (20 mL) at r.t. was added bromine (1.6 g, 0.51 mL, 10 mmol) dropwise. The reaction mixture was stirred for 2 h and then the product was isolated by filtration. The precipitate was washed twice with Et2O (100 mL) and then dried in vacuo to give the title compound in quantitative yield as a buff solid, which was used without further purification. LCMS (ES+) 190.9 (M+H)+.

後処理

  1. customthe product was isolated by filtration
  2. washThe precipitate was washed twice with Et2O (100 mL)
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-71186469f40b42658d4deaa0c35056b0
出典データセット
uspto-grants-2011_02
特許番号
US07888344B2

反応ノート

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