Chlorosulfonic acid → 1-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

HRID 1364188

反応式

HRID 1364188 の反応式
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[Cl:12][S:13](O)(=[O:15])=[O:14]>>[O:11]=[C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([S:13]([Cl:12])(=[O:15])=[O:14])[CH:9]=2)[CH2:4][CH2:3][NH:2]1

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 1508963,4-dihydroisoquinolin-1(2H)-one

生成物 1

HCID 180713741-Oxo-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

実験手順

To Chlorosulfonic acid (30 mL) is added 3,4-Dihydro-2H-isoquinolin-1-one (5 g, 34 mmol) at 0° C. After stirring at rt during 1 h, the mixture is heated at 50° C. during 16 h, then it is poured carefully into an ice bath and stirred at 0° C. during 30 min. The precipitate is filtered and dried in oven at 60° C. to give the title compound.

後処理

  1. temperaturethe mixture is heated at 50° C. during 16 h
  2. additionit is poured carefully into an ice bath
  3. stirringstirred at 0° C. during 30 min
  4. filtrationThe precipitate is filtered
  5. customdried in oven at 60° C.

出典と根拠

ORDレコード
ord-0cdbec0b6c6740fdb45be0f8d044b403
出典データセット
uspto-grants-2011_02
特許番号
US07888351B2

関連ノート

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