Methanol → Quinolin-8-ylmethanol

HRID 1364433

反応式

HRID 1364433 の反応式
[BH4-].[Na+].[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5](C=O)[CH:4]=1.[CH3:15][OH:16]>>[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH2:15][OH:16])[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 3

HCID 887MethanolHCID 836413-QuinolinecarboxaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 594412Quinolin-8-ylmethanol収率 75%

実験手順

Sodium borohydride (280 mg, 7.4 mmol) was added in portions to a solution of 3-quinoline-carboxaldehyde (1.06 g, 6.7 mmol) in methanol at room temperature. Reaction was quenched after 3 hours stirring with 10 mL (aq) sat. NH4Cl. Mixture was extracted with ethyl acetate (3×30 ml). Combined organics were washed with brine and dried over MgSO4. Crude material was purified by chromatography using (20-40% EA/Hex gradient) to afford quinolin-8-yl-methanol as an off white solid (800 mg; 75% yield).

後処理

  1. customReaction
  2. customwas quenched after 3 hours
  3. extractionMixture was extracted with ethyl acetate (3×30 ml)
  4. washCombined organics were washed with brine
  5. dry with materialdried over MgSO4
  6. customCrude material was purified by chromatography

出典と根拠

ORDレコード
ord-a0a5b2fa8a214858bb604d761aeba86c
出典データセット
uspto-grants-2011_02
特許番号
US07888366B2

関連ノート

読み込み中…