Water → N-(4-Amino-6-bromo-5-cyano-pyridin-2-yl)-acetamide
反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Br:10])[N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](Cl)([CH3:14])=[O:13].O>N1C=CC=CC=1>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Br:10])[N:5]=[C:4]([NH:11][C:12](=[O:13])[CH3:14])[CH:3]=1参加物
5
実験手順
4,6-Diamino-2-bromo-nicotinonitrile (100 mg, 0.47 mmol) was dissolved in 1.0 mL of anhydrous pyridine. AcCl (225 μL, 2.35 mmol) was dropped in slowly. The resulting mixture was shaken overnight at ambient temperature. Water (5 mL) was added to the mixture mixture. The resulting brown solid was collected through filtration, washed with cold water, and dried in a vacuum oven to provide the title compound (100 mg, 83%).
後処理
- filtrationThe resulting brown solid was collected through filtration
- washwashed with cold water
- customdried in a vacuum oven
出典と根拠
- ORDレコード
- ord-26722478daf54c5cb5495e98b9091a83
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888374B2
反応ノート
読み込み中…