Nitric Acid → 2-(2,5-Dimethoxy-4-nitrophenyl)acetic acid

HRID 1364551

反応式

HRID 1364551 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13].[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:15]([O-:17])=[O:16])[C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=[O:13]

参加物

5

反応物 2

HCID 944Nitric AcidHCID 744692,5-Dimethoxyphenylacetic acid

生成物 1

HCID 123157582-(2,5-Dimethoxy-4-nitrophenyl)acetic acid収率 69%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 962Water溶媒

実験手順

A solution of of 2,5-dimethoxyphenylacetic acid (1.00 g, 5.10 mmol) in 10 mL of acetic acid was added 6.5 mL of 1.0M HNO3 in acetic acid. The reaction was stirred at ambient temperature for 10 min, and diluted with 75 mL of water. The yellow precipitate was collected and washed with water (3×10 mL), then dried on the filter. Recrystallization from 20 mL of 2-propanol gave 846 mg (69%) of the titled compound as fine yellow crystals.

後処理

  1. customThe yellow precipitate was collected
  2. washwashed with water (3×10 mL)
  3. customdried on the filter
  4. customRecrystallization from 20 mL of 2-propanol

出典と根拠

ORDレコード
ord-1b6198da01a148ad9b38abc99bb3f0bf
出典データセット
uspto-grants-2011_02
特許番号
US07888374B2

関連ノート

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