Benzenepropanoic acid → (S)-4-Isopropyl-2-phenethyl-4,5-dihydrooxazole
反応式
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:12][C@H:13]([CH2:17]O)[CH:14]([CH3:16])[CH3:15]>ClC1C=CC=CC=1>[CH:14]([C@H:13]1[CH2:17][O:11][C:9]([CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:12]1)([CH3:16])[CH3:15]参加物
4
実験手順
Under an argon atmosphere, a mixture of 3-phenylpropionic acid (3.0 mmol), (L)-valinol (3.6 mmol), Zn4(OCOCF3)6O (0.15 mmol) and chlorobenzene (5 mL) was heated under reflux for 12 hours. From the resulting solution, the solvent was removed using an evaporator, and the residues were purified by silica gel column chromatography (hexane/ethyl acetate=10/1 (V/V)) to give (S)-4-isopropyl-2-(2-phenylethyl)-1,3-oxazoline in 86% yield.
後処理
- temperaturewas heated
- temperatureunder reflux for 12 hours
- customFrom the resulting solution, the solvent was removed
- customan evaporator
- customthe residues were purified by silica gel column chromatography (hexane/ethyl acetate=10/1 (V/V))
出典と根拠
- ORDレコード
- ord-a7970cc0ba3f48908a2f943eb9c439c1
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888513B2
反応ノート
読み込み中…