Hydrochloric Acid → HCID 178518410、化合物
反応式
[NH:1]([C:5]1[CH:9]=[CH:8][O:7][C:6]=1[C:10]([O:12]CC)=O)[C:2]([NH2:4])=[O:3].[OH-].[Na+].Cl>CO>[N:1]1[C:5]2[CH:9]=[CH:8][O:7][C:6]=2[C:10]([OH:12])=[N:4][C:2]=1[OH:3]参加物
5
実験手順
Ethyl 3-ureidofuran-2-carboxylate 35 (120 mg, 1.0 eq) was suspended in methanol (6 ml) and treated with 1.5 M NaOH (1.5 ml). Reaction mixture was heated to reflux for 90 minutes. Reaction mixture was allowed to cool down to room temperature, and was acidified with 6N HCl up to pH 3. Mixture was concentrated. Methanol was added to residue and solid was filtered and dried at 95° C. under high vacuum for 24 h to yield furo[3,2-d]pyrimidine-2,4-diol 36 (90 mg, 91%) which was used in the next reaction without further purification.
後処理
- customReaction mixture
- temperaturewas heated
- temperatureto reflux for 90 minutes
- customReaction mixture
- concentrationMixture was concentrated
- additionMethanol was added to residue and solid
- filtrationwas filtered
- customdried at 95° C. under high vacuum for 24 h
出典と根拠
- ORDレコード
- ord-e5b445e07d2d40e1b977b08607a48c76
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888352B2
反応ノート
読み込み中…