Ethanol sodium ethoxide → HCID 58962289、化合物
反応式
CS([O:5][C:6]1[C:15](=[O:16])[N:14]2[C:9]([C:10]3([CH2:20][CH2:19][CH2:18][CH2:17]3)[O:11][CH2:12][CH2:13]2)=[N:8][C:7]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])(=O)=O.CC[O-].[Na+].CCO>C1COCC1>[OH:5][C:6]1[C:15](=[O:16])[N:14]2[C:9]([C:10]3([CH2:20][CH2:19][CH2:18][CH2:17]3)[O:11][CH2:12][CH2:13]2)=[N:8][C:7]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22]参加物
4
実験手順
To a stirred suspension of ethyl 3′-(methylsulfonyloxy)-4′-oxo-6′,7′-dihydro-4′H-spiro[cyclopentane-1,9′-pyrimido[2,1-c][1,4]oxazine]-2′-carboxylate (0.6861 g, 1.84 mmol) in THF (50 mL) was added 1M EtONa/EtOH (10 mL). After 1 h, the resulting yellow solution was concentrated, acidified with 1 M aq. HCl (20 mL), extracted with CH2Cl2 (3×35 mL). The combined organic layers dried (Na2SO4), filtered and concentrated to give the title compound as a brown solid (0.4668 g, 86%). 1H NMR (500 MHz, CDCl3) δ: 10.49 (1H, s), 4.44 (2H, q, J=7.0 Hz), 4.03-3.97 (4H, m), 2.28-2.22 (2H, m), 2.06-2.01 (2H, m), 1.93-1.81 (4H, m), 1.42 (3H, t, J=7.0 Hz). HRMS (M+H) calcd for C14H19N2O5: 295.1294; found: 295.1293.