Diethyl bromomalonate → 5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester
反応式
[C:1]([NH2:4])(=[S:3])[CH3:2].Br[CH:6]([C:12](OCC)=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8]>C1(C)C=CC=CC=1>[CH2:10]([O:9][C:7]([C:6]1[S:3][C:1]([CH3:2])=[N:4][C:12]=1[OH:13])=[O:8])[CH3:11]参加物
4
実験手順
To a solution of thioacetamide (17.2 g, 0.229 mol) in toluene (130 mL) was added diethyl bromomalonate (55.0 g, 0.230 mol) and the mixture heated at reflux for 3 h. The reaction mixture was cooled to RT, filtered through Celite, then concentrated in vacuo. The resultant solid was triturated with hexane to give the title compound as a yellow solid (11.0 g, 26%).
後処理
- temperaturethe mixture heated
- temperatureat reflux for 3 h
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
- customThe resultant solid was triturated with hexane
出典と根拠
- ORDレコード
- ord-a8c5f6480d2d42cc9651a9312b388a40
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893060B2
反応ノート
読み込み中…