Hydrochloric Acid → 3-(2-Chloro-benzenesulfonyl)-cyclopentanecarboxylic acid

反応式

C[O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:6]1)=[O:4].[Li+].[OH-].Cl>CO>[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[S:10]([CH:7]1[CH2:8][CH2:9][CH:5]([C:3]([OH:4])=[O:2])[CH2:6]1)(=[O:12])=[O:11]

参加物

実験手順

A solution of 3-(2-chloro-benzenesulfonyl)-cyclopentanecarboxylic acid methyl ester (0.25 g, 1.0 eq) in methanol (8.0 mL) was treated with 1N LiOH (1.6 mL, 2.0 eq). The mixture was stirred at RT for 3 h and then acidified to pH 4 with HCl 1N. The methanol was evaporated and the residue extracted with ethyl acetate. The organic phase was dried over sodium sulfate and evaporated. The title compound was obtained as a colorless oil (0.25 g, 100%) and was used crude. MS (ESI): m/z=287.3 [M−H]−.