Trifluoroacetic acid → HCID 66918566、化合物
反応式
C([O:5][C:6]([CH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=2[Cl:23])(=[O:15])=[O:14])[CH2:9]1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:23][C:17]1[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:16]=1[S:13]([CH:10]1[CH2:11][CH2:12][CH:8]([C:6]([OH:7])=[O:5])[CH2:9]1)(=[O:15])=[O:14]参加物
4
実験手順
To a mixture of Rac-(1S,3S)-3-(2-Chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid tert-butyl ester (278 mg) in dichloromethane (4 mL) was added trifluoroacetic acid (1.34 g). The reaction mixture was stirred overnight at room temperature and the volatiles were removed in vacuo to afford the title compound (282 mg, quant.) as light brown oil, used in the next step without further purification. MS (EI): 305.1 (M−H)−.