4-Fluorophenol → (1R,2R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-fluoro-phenoxymethyl)-cyclopentanecarboxylic acid ethyl ester

HRID 1367537

反応式

HRID 1367537 の反応式
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9]([O:11][Si:12]([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13])[CH2:8][C@H:7]1[CH2:19][OH:20])=[O:5])[CH3:2].[F:21][C:22]1[CH:27]=[CH:26][C:25](O)=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9]([O:11][Si:12]([C:15]([CH3:16])([CH3:18])[CH3:17])([CH3:13])[CH3:14])[CH2:8][C@H:7]1[CH2:19][O:20][C:25]1[CH:26]=[CH:27][C:22]([F:21])=[CH:23][CH:24]=1)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 97324-FluorophenolHCID 59619451(1R,2R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-cyclopentanecarboxylic acid ethyl ester

生成物 1

HCID 66919037(1R,2R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-fluoro-phenoxymethyl)-cyclopentanecarboxylic acid ethyl ester

実験手順

The title compound was prepared in analogy to example 68 step 5 using (1R,2R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-cyclopentanecarboxylic acid ethyl ester (example 68 step 4) and 4-fluorophenol. Colorless oil (74%). MS (EI): 397.2 (M+H)+.

出典と根拠

ORDレコード
ord-9e0b5b62a35f4d3ba0d86c31311deb1b
出典データセット
uspto-grants-2011_02
特許番号
US07893099B2

関連ノート

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