Oxalyl chloride → 5-(Benzyloxy)pentanoyl chloride

HRID 1367665ノート

反応式

HRID 1367665 の反応式
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:19])=O>C1C=CC=CC=1>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([Cl:19])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 104205755-(Benzyloxy)pentanoic acid

生成物 1

HCID 102631205-(Benzyloxy)pentanoyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a solution of the acid 29 (4.98 g, 24 mmol) in dry benzene (40 ml), was added oxalyl chloride (2.5 ml, 28.8 mmol, 1.2 equiv) dropwise. A drying tube was placed on the flask and the reaction was stirred for 90 min at room temperature. The reaction was concentrated in vacuo and used directly in the next step: 1H NMR (400 MHz, CDCl3) δ 7.38-7.27 (m, 5H), 4.50 (s, 2H), 3.51-3.40 (t, 3J=6.4 Hz, 2H), 2.95-2.90 (t, 3J=7.2 Hz, 3H), 1.87-1.78 (m, 2H), 1.71-1.63 (m, 2H); 13C NMR (75 MHz, CDCl3) δ 173.958, 138.519, 128.949, 128.787, 128.630, 127.862, 73.197, 69.551, 47.032, 28.618, 22.329.

後処理

  1. customA drying tube was placed on the flask
  2. concentrationThe reaction was concentrated in vacuo

出典と根拠

ORDレコード
ord-1d18e44234d34735bf07cd7d56a45342
出典データセット
uspto-grants-2011_02
特許番号
US07893268B2

反応ノート

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