Phenacyl bromide → HCID 178474414、化合物
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[C:11]([NH:14][C:15]([NH2:17])=[NH:16])(=[O:13])[CH3:12]>CN(C=O)C.CCOC(C)=O>[C:5]1([C:3]2[N:16]=[C:15]([NH:14][C:11](=[O:13])[CH3:12])[NH:17][CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
5
実験手順
To a solution of 2.0 g (10 mmol) of 2-bromoacetophenone in DMF (30 mL) was added 3.0 g (29 mmol) 1-acetylguanidine in one portion, the reaction mixture was stirred at rt for 2 days. The reaction mixture was diluted with EtOAc (250 mL) and washed with saturated NH4Cl aq. solution (50 mL). The organic phase was dried over MgSO4 and concentrated under vacuum. The residue was purified by a flash column chromatography eluting with EtOAc to give N-(4-phenyl-1H-imidazol-2-yl)-acetamide. (0.5 g, 24%). LCMS: 203 (M+1)+.
後処理
- washwashed with saturated NH4Cl aq. solution (50 mL)
- dry with materialThe organic phase was dried over MgSO4
- concentrationconcentrated under vacuum
- customThe residue was purified by a flash column chromatography
- washeluting with EtOAc
出典と根拠
- ORDレコード
- ord-b4bae55fc8414f109c534a56b0c32ed6
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893267B2
反応ノート
読み込み中…