Water → 2,2-diethoxyethyl Benzoate

HRID 13681

反応式

HRID 13681 の反応式
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5]Cl)[CH3:2].[C:10]([O-:18])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[K+].CN(C=O)C.O>C(OCC)(=O)C>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][O:18][C:10](=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 6228DimethylformamideHCID 121282-Chloro-1,1-diethoxyethaneHCID 23661960Potassium Benzoate

生成物 1

HCID 118172582,2-diethoxyethyl Benzoate収率 30%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Chloroacetaldehyde diethyl acetal (1.9 g), potassium benzoate (2.0 g) and DMF (20 mL) were placed in a three-neck flask, followed by refluxing. Twenty hours later, the reaction mixture was cooled to room temperature, and water (60 mL) and ethyl acetate (80 mL) were added thereto, followed by stirring. After filtration and separation, the organic layer was concentrated and thereby yielded the target compound (0.69 g) in a yield of 30%.

後処理

  1. temperatureby refluxing
  2. filtrationAfter filtration and separation
  3. concentrationthe organic layer was concentrated

出典と根拠

ORDレコード
ord-ab04dd03fbe84d7fa44f135c7f0202f5
出典データセット
uspto-grants-2010_06
特許番号
US07728152B2

関連ノート

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