Formic Acid → HCID 178487492、化合物

HRID 1368509

反応式

HRID 1368509 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([C:15]1[N:16]=[CH:17][N:18](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:19]=1)=[O:14])[CH:7]=[CH:6]2.C(O)=O.[CH2:42]1[CH2:46]OC[CH2:43]1>>[NH:18]1[CH:19]=[C:15]([C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)([OH:14])[CH:42]([CH3:46])[CH3:43])[N:16]=[CH:17]1

参加物

4

反応物 3

HCID 284Formic AcidHCID 8028TetrahydrofuranHCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

生成物 1

HCID 178487492HCID 178487492、化合物

反応条件

温度
50 °C

実験手順

(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (15.0 g) was dissolved in THF (80 ml). To the solution was added 90% formic acid (20 ml), and the mixture was stirred at 50° C. for 2 h. After removal of the solvents by evaporation, 1N-hydrochloric acid (60 ml) was added and the precipitate was filtered off. The filtrate was washed with ether, and neutralized with potassium carbonate. The resulting precipitate was collected by filtration, dried under reduced pressure to give the titled compound (7.54 g) as a colorless solid.

後処理

  1. customAfter removal of the solvents
  2. customby evaporation, 1N-hydrochloric acid (60 ml)
  3. additionwas added
  4. filtrationthe precipitate was filtered off
  5. washThe filtrate was washed with ether
  6. filtrationThe resulting precipitate was collected by filtration
  7. customdried under reduced pressure

出典と根拠

ORDレコード
ord-6db7d0a9eed2440bbe8e310b76c2ae5a
出典データセット
uspto-grants-2003_06
特許番号
US06573289B1

関連ノート

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