Tetrahydrofuran → HCID 178475354、化合物

HRID 1368521ノート

反応式

HRID 1368521 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]([C:24]1[N:25]=[CH:26][N:27](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:28]=1)([OH:23])[CH:20]([CH3:22])[CH3:21])[CH:13]=[CH:12]2)[C:2]1C=CC=CC=1.C1C[O:51]CC1>CO.[C].[Pd]>[C:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]([C:24]1[N:25]=[CH:26][NH:27][CH:28]=1)([OH:23])[CH:20]([CH3:22])[CH3:21])[CH:13]=[CH:12]2)(=[O:51])[CH3:2]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 220183201-(6-Benzyloxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

生成物 1

HCID 178475354HCID 178475354、化合物

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

1-(6-Benzyloxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (2.4 g) was dissolved in a mixed solution of THF and methanol (1:1, 160 ml). To the solution was added 10% palladium carbon (0.8 g). The mixture was stirred for 5 h under hydrogen atmosphere. The catalyst was filtered off, and filtrate was concentrated. The residue was crystallized from THF-ethyl acetate to give the titled compound (1.20 g) as a colorless powder.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated
  3. customThe residue was crystallized from THF-ethyl acetate

出典と根拠

ORDレコード
ord-959cb9315314400db442fa4a1f5db3c7
出典データセット
uspto-grants-2003_06
特許番号
US06573289B1

反応ノート

読み込み中…