Acetic Acid → HCID 178475354、化合物

HRID 1368522

反応式

HRID 1368522 の反応式
O[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2.N1C=CC=CC=1.[C:47]([OH:50])(=[O:49])[CH3:48]>>[C:47]([O:50][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2)(=[O:49])[CH3:48]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 1049PyridineHCID 220183856-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthol

生成物 1

HCID 178475354HCID 178475354、化合物

実験手順

A mixture of 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (1.0 g), pyridine (4 ml) and anhydrous acetic acid (4 ml) was stirred at room temperature for 14 h. The reaction mixture was concentrated to dryness, and the residue was dissolved in ethyl acetate and washed with water and saturated aqueous solution of sodium chloride. The solution was dried and concentrated. The residue was crystallized from ethyl acetate-diisopropyl ether to give the titled compound (0.6 g) as a colorless powder.

後処理

  1. concentrationThe reaction mixture was concentrated to dryness
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with water and saturated aqueous solution of sodium chloride
  4. customThe solution was dried
  5. concentrationconcentrated
  6. customThe residue was crystallized from ethyl acetate-diisopropyl ether

出典と根拠

ORDレコード
ord-4c6348e8c0ec41f5a301822bcf38763d
出典データセット
uspto-grants-2003_06
特許番号
US06573289B1

関連ノート

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