Ethanol → 6-Ethoxy-3-nitropyridin-2-amine

HRID 1370194ノート

反応式

HRID 1370194 の反応式
[H-].[Na+].[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[C:6](Cl)[N:5]=1.[CH2:14]([OH:16])[CH3:15]>>[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[C:6]([O:16][CH2:14][CH3:15])[N:5]=1

参加物

4

反応物 3

HCID 702EthanolHCID 24758Sodium hydrideHCID 27240356-Chloro-3-nitropyridin-2-ylamine

生成物 1

HCID 132457716-Ethoxy-3-nitropyridin-2-amine

実験手順

2.4 g of 60% sodium hydride was slowly added to 100 ml of ethanol and stirred as it was at room temperature for 10 minutes. 10 g of 2-amino-6-chloro-3-nitropyridine was added thereto and reacted at room temperature for 30 minutes. After concentration, water was added thereto, and it was extracted with ethyl acetate. It was washed with water and brine sucsessively, and dried over anhydrous sodium sulfate. After concentration, 9.7 g of the title compound was obtained.

後処理

  1. customreacted at room temperature for 30 minutes
  2. concentrationAfter concentration, water
  3. additionwas added
  4. extractionit was extracted with ethyl acetate
  5. washIt was washed with water and brine sucsessively
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationAfter concentration

出典と根拠

ORDレコード
ord-cb8a7275956a4321b4f8d8517092a4ce
出典データセット
uspto-grants-2003_06
特許番号
US06583138B1

反応ノート

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