Benzaldehyde → Methyl (4R)-2-phenyl-1,3-thiazolidine-4-carboxylate
反応式
Cl.[CH3:2][O:3][C:4](=[O:9])[C@H:5]([CH2:7][SH:8])[NH2:6].[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C>O1CCCC1>[C:11]1([CH:10]2[NH:6][C@H:5]([C:4]([O:3][CH3:2])=[O:9])[CH2:7][S:8]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
5
実験手順
To a suspension of L-cysteine methyl ester hydrochloride (1.717 g, 10 mmol) in tetrahydrofuran (5.0 mL) at room temperature under nitrogen was added benzaldehyde (1.02 mL, 10 mmol) followed by triethylamine (4.2 mL, 30 mmol). After stirring at room temperature for 3.5 hrs, the resulting mixture was filtered through a pad of silica gel eluting with EtOAc. Evaporation of the filtrate gave the title compound (1.95 g, 88%) as a colorless oil. TLC(EtOAc-hexane; 1:5) Rf=0.22.
後処理
- filtrationthe resulting mixture was filtered through a pad of silica gel eluting with EtOAc
- customEvaporation of the filtrate
出典と根拠
- ORDレコード
- ord-2194b992c06a4819a26c6ca96d373f8c
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157430B2
反応ノート
読み込み中…