Ammonium Hydroxide → 8-Amino-3-bromoimidazo[1,2-a]pyrazine
反応式
[Br:1][C:2]1[N:6]2[C:7](Br)=[CH:8][N:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[NH4+:12].[OH-]>C1COCC1.C(Cl)Cl.Cl>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH2:12])[C:5]2=[N:4][CH:3]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (500 mg, 1.8 mmol) in THF (4 ml) was added NH4OH (4 ml). The mixture was heated at 50° C. in sealed tube overnight. Additional NH4OH (4 ml) was added to the reaction mixture and was heated at 50° C. in sealed tube overnight. The mixture was then cooled to rt, diluted with DCM (200 ml) and IN HCl (50 ml). The organic layer was washed with 10N NaOH, brine, dried and concentrated. The residue was purified on a silica gel column to afford 190 mg (yield 50%) of 3-bromo-imidazo[1,2-a]pyrazin-8-ylamine.
後処理
- temperaturewas heated at 50° C. in sealed tube overnight
- temperatureThe mixture was then cooled to rt
- washThe organic layer was washed with 10N NaOH, brine
- customdried
- concentrationconcentrated
- customThe residue was purified on a silica gel column
出典と根拠
- ORDレコード
- ord-b181ee225a8f4457875217f656dc2c35
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157460B2
反応ノート
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