Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl- → N-Methylimidazo[1,2-A]pyrazin-8-amine
反応式
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH3:12])[C:5]2=[N:4][CH:3]=1>CO.[Pd]>[N:4]1[CH:3]=[CH:2][N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH3:12])[C:5]=12参加物
4
実験手順
To a solution of (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-methyl-amine (Example 1) (2.4 g, 11.9 mmol) in methanol (160 ml) was added Pd-C (10% wt. 0.1 eq). The mixture was hydrogenated at rt overnight, filtered, and washed with hot methanol. The organics were combined and concentrated to afford 2.8 g of crude imidazo[1,2-a]pyrazin-8-yl-methyl-amine (M).
後処理
- filtrationfiltered
- washwashed with hot methanol
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2472619a08234b0a870c8ef98436cd41
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157460B2
反応ノート
読み込み中…