2,6-Dichloro-4-isocyanatopyridine → N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}N'-(2,6-dichloropyridin-4-yl)urea

HRID 1371423

反応式

HRID 1371423 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Cl:18][C:19]1[CH:24]=[C:23]([N:25]=[C:26]=[O:27])[CH:22]=[C:21]([Cl:28])[N:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:26]([NH:25][C:23]2[CH:22]=[C:21]([Cl:28])[N:20]=[C:19]([Cl:18])[CH:24]=2)=[O:27])[CH2:7]1

参加物

3

反応物 2

HCID 27816582,6-Dichloro-4-isocyanatopyridineHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

生成物 1

HCID 10183254N-{[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methyl}N'-(2,6-dichloropyridin-4-yl)urea収率 39.1%

実験手順

Example 24 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 2,6-dichloro-4-isocyanatopyridine (0.0258 g) to give the title compound (0.0165 g). LC-MS (System A): Rt 2.46 mins, Mass Spectrum m/z 463 [MH+].

後処理

  1. customExample 24 was prepared in an analogous manner to Example 1 using

出典と根拠

ORDレコード
ord-fb45000ffe6b4b209ec323ca48bb05f5
出典データセット
uspto-grants-2007_01
特許番号
US07157457B2

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