1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole → 1-(Piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1 H-benzoimidazole

HRID 1371505ノート

反応式

HRID 1371505 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:17]=3[N:16]=[C:15]2[C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:17]=3[N:16]=[C:15]2[C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 179896571-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole

生成物 1

HCID 179896551-(Piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1 H-benzoimidazole収率 86.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

5.7 g 1-(1-Benzyl-piperidin-4-yl)-5-fluoro-2-pentafluoroethyl-1H-benzoimidazole were dissolved in 100 ml methanol and hydrogenated with 2 g Pd/C (10%) at 50° C. and 60 psi for 2 h. The catalyst was removed and the filtrate was evaporated. The residue was crystallized with diisopropyl ether and petrol ether 1:1 to yield 3.9 g beige crystals (mp. 177–178° C.).

後処理

  1. customThe catalyst was removed
  2. customthe filtrate was evaporated
  3. customThe residue was crystallized with diisopropyl ether and petrol ether 1:1

出典と根拠

ORDレコード
ord-8acd6fef4b4545598c7ea5d270b38fdc
出典データセット
uspto-grants-2007_01
特許番号
US07157471B2

反応ノート

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