Sodium Azide → Methyl 4-(azidomethyl)benzoate
反応式
[N-:1]=[N+:2]=[N-:3].[Na+].Br[CH2:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=1>CS(C)=O>[N:1]([CH2:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=1)=[N+:2]=[N-:3]参加物
4
実験手順
8.13 g of sodium azide are added over 5 minutes to a solution of 5.73 g of methyl 4-(bromomethyl)benzoate in 30 ml of DMSO and the mixture is stirred for 3 hours 30 minutes at RT. The reaction mixture is extracted with ether, the organic phase is washed with water and with saturated NaCl solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 4.72 g of the expected product are obtained in the form of a colourless oil.
後処理
- extractionThe reaction mixture is extracted with ether
- washthe organic phase is washed with water and with saturated NaCl solution
- dry with materialdried over Na2SO4
- customthe solvent is evaporated off under vacuum
出典と根拠
- ORDレコード
- ord-e3bb5b6f27604497964eb5092f74ffab
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157454B2
反応ノート
読み込み中…