関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | 3-Formyl-1H-indole-5-carbonitrile | HCID 28504 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 生成物 | 2-Nitrovinyl-5-cyano-1H-indole | HCID 69850620 | — |
反応手順
Combine 3-formyl-5-cyano-1H-indole (10.60 g, 63.32 mmol) and a solution of ammonium acetate (10.60 g) in nitromethane (660 ml). Heat to 90° C. After 2 hours, cool to ambient temperature to give a precipitate. Collect the precipitate by filtration, wash with 1:1 MeOH/water (500 ml), and dry to give the title compound: mp 247–251° C. MS (ACPI): m/e 214.0 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07157488B2 |
|---|
| 出典データセット | uspto-grants-2007_01 |
|---|
| ORD ID | ord-6ff82343e32349d3b0127c8cde43532f |
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| 出典メモ | uspto-grants-2007_01 |
|---|
