反应详情

温度

90 °C

Combine 3-formyl-5-cyano-1H-indole (10.60 g, 63.32 mmol) and a solution of ammonium acetate (10.60 g) in nitromethane (660 ml). Heat to 90° C. After 2 hours, cool to ambient temperature to give a precipitate. Collect the precipitate by filtration, wash with 1:1 MeOH/water (500 ml), and dry to give the title compound: mp 247–251° C. MS (ACPI): m/e 214.0 (M+1).

1. temperaturecool to ambient temperature
2. customto give a precipitate
3. customCollect the precipitate
4. filtrationby filtration
5. washwash with 1:1 MeOH/water (500 ml)
6. customdry