Chlorosuccinimide → 4-Chloro-5-isopropyl-3-trifluoromethylpyrazole

HRID 1372014ノート

反応式

HRID 1372014 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[NH:5][N:4]=1.C1C(=O)N([Cl:20])C(=O)C1>CC#N>[Cl:20][C:7]1[C:3]([C:2]([F:1])([F:11])[F:12])=[N:4][NH:5][C:6]=1[CH:8]([CH3:10])[CH3:9]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 230062143-(trifluoroMethyl)-5-isopropyl-1H-pyrazole

生成物 1

HCID 210711494-Chloro-5-isopropyl-3-trifluoromethylpyrazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Following protocol L, to the solution of 3-trifluoromethyl-5-isopropyl-pyrazole (0.22 g, 1.23 mmol) in CH3CN (10 mL) was added NCS (0.19 g, 1.43 mmol) in portions with vigorous stirring. The reaction mixture was then heated under reflux for 14 h, cooled and the reaction quenched with saturated NaHCO3, extracted with methylene chloride (2×30 mL) and the combined organic extracts was washed with brine, dried with Na2SO4 and evaporated to give the title compound as a white solid.

後処理

  1. temperatureThe reaction mixture was then heated
  2. temperatureunder reflux for 14 h
  3. temperaturecooled
  4. customthe reaction quenched with saturated NaHCO3
  5. extractionextracted with methylene chloride (2×30 mL)
  6. washthe combined organic extracts was washed with brine
  7. dry with materialdried with Na2SO4
  8. customevaporated

出典と根拠

ORDレコード
ord-9366c7670978460d8299927a4adb9d2b
出典データセット
uspto-grants-2007_01
特許番号
US07157464B2

反応ノート

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