Dimethylformamide → 1-[4-(4-Bromo-3-methoxyphenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone

関与物質

役割	名称	HCID	仕込み量
反応物	Dimethylformamide	HCID 6228	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone	HCID 21071125	—
反応物	HCID 178506302	HCID 178506302	—
溶媒	Ethyl acetate hexane	HCID 21226206	—
生成物	1-[4-(4-Bromo-3-methoxyphenyl)-piperazin-1-yl]-2-(4-chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone	HCID 21070978	—

反応手順

Protocol T was followed using 4-Chloro-5-phenyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3:Rf=0.58) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 7.81–7.86 (m, 1H), 7.36–7.44 (m, 4H), 6.42–6.48 (d, 1H), 6.34–6.38 (dd, 2H), 5.2 (s, 2H), 3.88 (s, 3H), 3.62–3.82 (m, 4H), 3.12–3.22 (m, 4H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07157464B2
出典データセット	uspto-grants-2007_01
ORD ID	ord-154b10051796452caa2698dc42296708
出典メモ	uspto-grants-2007_01