Sodium Hydroxide → (2-(4-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid

HRID 1372647ノート

反応式

HRID 1372647 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[O:10][C:11]3[C:17]([F:18])=[C:16]([CH2:19][C:20]([O:22]C)=[O:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([CH3:24])[CH:3]=1.[OH-].[Na+]>C1COCC1.CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[O:10][C:11]3[C:17]([F:18])=[C:16]([CH2:19][C:20]([OH:22])=[O:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([CH3:24])[CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58778975Methyl (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetate

生成物 1

HCID 17859146(2-(4-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid収率 109.2%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

In THF/methanol (2:1, v/v, 120 ml) was dissolved methyl (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetate (1.32 g, 3.97 mmol). To the resulting solution was added 1N NaOH (40 ml). After stirring at room temperature for 12 hours, the reaction mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(4-fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl)acetic acid (1.38 g, 100%) as a colorless solid.

後処理

  1. distillationthe reaction mixture was distilled under reduced pressure
  2. customto remove the solvent
  3. customThe crystals thus precipitated
  4. filtrationwere collected by filtration under reduced pressure
  5. washwashed with water
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-de0275cc87394541807685925831e4da
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

反応ノート

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