Water → Indazole-3-carboxylic acid
反応式
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=[O:14])=[N:5]1)(=O)C.[OH-].[Na+].O>Cl>[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([OH:15])=[O:14])=[N:5]1参加物
5
反応条件
- 温度
- 65 °C
実験手順
To methyl 1-acetylindazole-3-carboxylate (22.3 g, 0.10 mol) were added sodium hydroxide (8.18 g, 0.20 mol) and water (640 ml) and the resulting mixture was stirred at 60 to 70° C. for 6.5 hours. The reaction mixture was poured in concentrated HCl (30 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give indazole-3-carboxylic acid (17.6 g, 100%) as a pale yellow solid.
後処理
- customThe crystals thus precipitated
- filtrationwere collected by filtration under reduced pressure
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-0360e4640d5a40cf84a61038dc4d5b79
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157487B2
反応ノート
読み込み中…