Sodium Hydroxide → (5-Chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid

HRID 1372792ノート

反応式

HRID 1372792 の反応式
[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([O:11]CC)=[O:10])[CH:7]=1.[OH-].[Na+]>CO.Cl>[Cl:1][C:2]1[C:3]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])=[CH:4][C:5]([F:14])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 44606313Ethyl (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetate

生成物 1

HCID 17859254(5-Chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid収率 98%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

Ethyl (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetate (531 mg, 1.41 mmol) was dissolved in methanol (50 ml). To the resulting solution was added 0.25N NaOH (12 ml, 3 mmol). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was poured in 1N HCl (100 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure for 15 hours to give (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid (480 mg, 98%) as a colorless crystalline powder.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure for 15 hours

出典と根拠

ORDレコード
ord-60251fd8e08b4f8a97d74fa488b643f8
出典データセット
uspto-grants-2007_01
特許番号
US07157487B2

反応ノート

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