3-Fluorobenzaldehyde → (E)-3-(3-Fluorophenyl)-2-(4-pyridyl)-2-propenenitrile

反応式

[Na].Cl.[N:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>C(O)C>[F:12][C:13]1[CH:14]=[C:15](/[CH:16]=[C:9](\[C:6]2[CH:7]=[CH:8][N:3]=[CH:4][CH:5]=2)/[C:10]#[N:11])[CH:18]=[CH:19][CH:20]=1

参加物

実験手順

Sodium (3.0 g, 130 mmol) was dissolved in ethanol (150 mL), 4-pyridylacetonitrile hydrochloride (10 g, 65 mmol) was added thereto, and then the mixture was stirred at room temperature. After 10 minutes, 3-fluorobenzaldehyde (8 g, 65 mmol) was added thereto, followed by stirring as it was for 30 minutes. The resulting precipitates were collected by filtration and washed with a small portion of water, to give the title compound (8.2 g, 56%) as a colorless solid.