Hydrogen Bromide → HCID 23020487、化合物
反応式
Br.[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:12]=[N:13][C:14]([O:17]C)=[CH:15][CH:16]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1>C(O)(=O)C>[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][CH:12]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1参加物
4
実験手順
In a mixture solution of acetic acid and 48% hydrogen bromide, 2-amino-6-(3-fluorophenyl)-5-(6-methoxy-3-pyridyl)-3-methyl-3,4-dihydro-4-pyrimidinone was stirred at 100° C. for 2 hours. After cooling, the reaction solution was basified and washed with ethyl acetate. The aqueous layer was neutralized with diluted hydrochloric acid, and the resulting solid was collected by filtration, to give the title compound.
後処理
- temperatureAfter cooling