Sodium Hydroxide → 3-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

HRID 1373138ノート

反応式

HRID 1373138 の反応式
[OH-].[Na+].C([N:6]1[C:14]2[C:9](=[CH:10][C:11]([N:15](C(=O)C)[S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[CH:12][CH:13]=2)[C:8](=[C:28]([O:35][CH2:36][CH3:37])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:7]1=[O:38])(=O)C>ClCCl.C(O)C>[CH2:36]([O:35][C:28](=[C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:17])=[O:18])[CH:10]=2)[NH:6][C:7]1=[O:38])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:37]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 695098291-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone

生成物 1

HCID 695105493-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

8 ml of 4 N sodium hydroxide solution are added to a solution of 4.0 g (8 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone (Example 1e) in a mixture of 20 ml of dichloromethane and 20 ml of ethanol and the resulting mixture is stirred for 20 minutes at ambient temperature. It is then evaporated down to about. 10 ml and 150 ml of water are added. The pH is adjusted to 8–9 with 1 N hydrochloric acid. The precipitate formed is suction filtered, washed with water, isopropanol and ether, then dried in vacuo.

後処理

  1. customIt is then evaporated down to about
  2. addition10 ml and 150 ml of water are added
  3. customThe precipitate formed
  4. filtrationfiltered
  5. washwashed with water, isopropanol and ether
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-ba86cf0e17ae4f448c9a4d64932f3d8f
出典データセット
uspto-grants-2007_01
特許番号
US07160901B2

反応ノート

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