Sodium Iodide → 4-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

HRID 1373159ノート

反応式

HRID 1373159 の反応式
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8].[I-:19].[Na+].C(OC)(C)(C)C>CC(C)=O>[I:19][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[O:6][C:7]=1[CH3:8]

参加物

5

反応物 3

HCID 5238Sodium IodideHCID 15413tert-Butyl methyl etherHCID 121580734-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole

生成物 1

HCID 210742684-Iodomethyl-5-methyl-2-naphthalen-2-yloxazole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1.8 g of 4-chloromethyl-5-methyl-2-naphthalen-2-yloxazole and 3 g of sodium iodide in 150 ml of acetone are heated under reflux for 2 hours. After the reaction mixture has been cooled, 300 ml of methyl tert-butyl ether are added, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4 and the solvents are then removed under reduced pressure. This gives 2.7 g of 4-iodomethyl-5-methyl-2-naphthalen-2-yloxazole as a light-yellow solid.

後処理

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter the reaction mixture has been cooled
  3. washthe mixture is washed three times with saturated Na2S2O3 solution
  4. dry with materialdried over MgSO4
  5. customthe solvents are then removed under reduced pressure

出典と根拠

ORDレコード
ord-fd05c981796b448b8502a53815ae871b
出典データセット
uspto-grants-2007_01
特許番号
US07160911B2

反応ノート

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