1-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazine → 7-{4-[4-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

HRID 1373616

反応式

HRID 1373616 の反応式
[C:1]1([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[O:17]=[C:18]1[NH:27][C:26]2[N:25]=[C:24]([O:28][CH2:29][CH2:30][CH2:31][CH:32]=O)[CH:23]=[C:22]([C:34]([F:37])([F:36])[F:35])[C:21]=2[CH2:20][CH2:19]1>>[C:1]1([N:11]2[CH2:16][CH2:15][N:14]([CH2:32][CH2:31][CH2:30][CH2:29][O:28][C:24]3[N:25]=[C:26]4[C:21]([CH2:20][CH2:19][C:18](=[O:17])[NH:27]4)=[C:22]([C:34]([F:36])([F:35])[F:37])[CH:23]=3)[CH2:13][CH2:12]2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 986981-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazineHCID 210733764-(7-Oxo4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde

生成物 1

HCID 210737057-{4-[4-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

実験手順

In a manner similar to that of other examples above, 1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-piperazine was coupled by reductive amination to 4-(7-oxo-4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 503.1 (Exact Mass: 502.26).

後処理

  1. customfollowed by typical workup and purification

出典と根拠

ORDレコード
ord-7b3c6ee8403349ebbc719e70bc756807
出典データセット
uspto-grants-2007_01
特許番号
US07160888B2

関連ノート

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