Acetic Acid → 5-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide

HRID 1373715ノート

反応式

HRID 1373715 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19]([CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[O:20])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8].[CH3:27][N:28]1[CH2:34][CH2:33][CH2:32][C:31](=O)[CH2:30][CH2:29]1.[BH3-]C#N.[Na+].C(O)(=O)C>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:18][C:19]([CH:21]2[CH2:22][CH2:23][N:24]([CH:31]3[CH2:32][CH2:33][CH2:34][N:28]([CH3:27])[CH2:29][CH2:30]3)[CH2:25][CH2:26]2)=[O:20])=[C:6]([CH:17]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1)=[O:8]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 2625861-Methylazepan-4-oneHCID 5003444Sodium cyanoborohydrideHCID 210753345-chloro-2-(piperidin-4-ylcarbonylamino)-N-(5-chloropyridin-2-yl)-benzamide

生成物 1

HCID 210753175-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound is prepared from 5-chloro-2-(piperidin-4-ylcarbonylamino)-N-(5-chloropyridin-2-yl)-benzamide and 1-methyl-hexahydro-4H-azepin-4-one by reductive alkylation using NaCNBH3 and 5%-acetic acid in methanol, for example using a procedure similar to that of Example 25-F.

出典と根拠

ORDレコード
ord-f3ea6a1a0d5a4e8ab9034749e7fa23fe
出典データセット
uspto-grants-2007_01
特許番号
US07163938B2

反応ノート

読み込み中…