Glutaric anhydride → 5-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid

HRID 1374587ノート

反応式

HRID 1374587 の反応式
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[N:9]1([CH2:15][C:16]([N:18](C)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:17])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.O1CCOC[CH2:27]1>>[CH3:27][CH:15]([C:16](=[O:17])[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[N:9]1[CH2:14][CH2:13][N:12]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:11][CH2:10]1

参加物

4

反応物 3

HCID 7940Glutaric anhydrideHCID 312751,4-DioxaneHCID 2737187N-methyl-N-phenyl-2-(piperazin-1-yl)acetamide

生成物 1

HCID 695033575-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid

反応条件

温度
25 °C

実験手順

1.517 g of glutaric anhydride and then 1.715 g of N-[2-(piperazin-1-yl)acetyl]-N-methylaniline are added to 15 cm3 of dioxane. After stirring for 19 hours at 25° C., the white precipitate formed is filtered on No. 4 sintered glass, rinsed with dioxane and then with diethyl ether and then dried at 20° C. (90 Pa) to give 2 g of 5-[4-(methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid in the form of a white solid which is used as it is.

後処理

  1. customthe white precipitate formed
  2. filtrationis filtered on No
  3. wash4 sintered glass, rinsed with dioxane
  4. dry with materialwith diethyl ether and then dried at 20° C. (90 Pa)

出典と根拠

ORDレコード
ord-39a99c2913fe4965814b43325565eac7
出典データセット
uspto-grants-2007_01
特許番号
US07166594B2

反応ノート

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