Water → 1-(2-Chlorophenyl)cyclopropanecarbonitrile

HRID 1374628ノート

反応式

HRID 1374628 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]#[N:10].Br[CH2:12][CH:13](Br)C.[H-].[Na+].O>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([C:9]#[N:10])[CH2:13][CH2:12]1

参加物

6

反応物 4

HCID 962WaterHCID 65531,2-DibromopropaneHCID 24758Sodium hydrideHCID 76112(o-Chlorophenyl)acetonitrile

生成物 1

HCID 103133551-(2-Chlorophenyl)cyclopropanecarbonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 13.1 g of 2-chlorophenylacetonitrile and 20.3 g of 1,2-dibromopropane in 142 ml of DMF is mixed with 9 g of sodium hydride [55–65% in oil] at room temperature. It is stirred for several hours and carefully added to water. After extraction with ethyl acetate and filtration by silica gel, the desired product is obtained: 13.1 g

後処理

  1. extractionAfter extraction
  2. filtrationwith ethyl acetate and filtration by silica gel

出典と根拠

ORDレコード
ord-e765fb82ca28462e87cacf9505a74cd1
出典データセット
uspto-grants-2007_01
特許番号
US07166592B2

反応ノート

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